Newfound clarity for bio­polymers

The new Nexera XS inert improves the analysis of biopharmaceuticals

The new bio-inert, biocompatible UHPLC system – developed together with Kyoto University – provides better reliability, robustness and expandability. The corrosion-resistant system is best suited to the analysis of biopolymers thanks to its metal-free sample flow path.

The new Nexera XS inert is a bio-inert and biocompatible ultra-high performance liquid chromatography (UHPLC) system. Shimadzu specifically developed the system to solve the most common problems in biopharmaceutical analysis, such as the adsorption of target molecules on metal surfaces and corrosion due to mobile phases with high salinity and extreme pH values. The development of the Nexera XS inert is based on the results of joint research with Professor Yasushi Ishihama of the Graduate School of Pharmaceutical Sciences at Kyoto University.

The system has a metal-free sample flow path that prevents unwanted interactions with biopolymers, which tend to be adsorbed at exposed metal sites. Therefore, the Nexera XS inert achieves reduced sample loss and excellent peak shape for reproducibly high sensitivity and high-quality, reliable data. In addition, all the contact surfaces are made from corrosion-resistant materials, which makes them stable against mobile phases that contain high concentrations of salts or acids.

There are also other new and advanced features such as bio-inert column switching, UHPLC connections that can be tightened by hand without additional tools (“finger tight”) and real-time pH monitoring.

Nexera XS inert provides the same outstanding reliability, robustness and expandability as the other UHPLC systems of the Nexera series. It is especially suited to the analysis of biopolymers such as antibodies, peptides and nucleic acid medicines.

Bio-inert and biocompatible UHPLC: the Nexera XS inert